Folate (categories)
Folate range (<45.3 vs >=45.3)
Global tests
Type III ANOVA on main and interaction effects, and LM model summaries.
PRL (ng/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
231.6615844
|
1
|
<0.0001
|
***
|
|
Folate_gp
|
3.4750812
|
1
|
0.06
|
ns
|
|
Study
|
0.1842697
|
1
|
0.7
|
ns
|
|
GA_samp
|
173.4460939
|
1
|
<0.0001
|
***
|
|
Folate_gp:Study
|
0.9042110
|
1
|
0.3
|
ns
|
hPL (μg/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
43.4448740
|
1
|
<0.0001
|
***
|
|
Folate_gp
|
0.0364404
|
1
|
0.8
|
ns
|
|
Study
|
15.0574283
|
1
|
0.0001
|
***
|
|
GA_samp
|
2495.8520938
|
1
|
<0.0001
|
***
|
|
Folate_gp:Study
|
0.2603451
|
1
|
0.6
|
ns
|
GH2 (ng/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
426.8274799
|
1
|
<0.0001
|
***
|
|
Folate_gp
|
0.0062344
|
1
|
0.9
|
ns
|
|
Study
|
0.0027234
|
1
|
1.0
|
ns
|
|
GA_samp
|
1070.4519710
|
1
|
<0.0001
|
***
|
|
Folate_gp:Study
|
1.4933308
|
1
|
0.2
|
ns
|
Insulin (uU/ml)
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
Folate_gp
|
1
|
Inf
|
3.067
|
3.067
|
0.08
|
ns
|
|
3
|
Study
|
1
|
Inf
|
11.682
|
11.682
|
0.0006
|
***
|
|
4
|
GA_samp
|
1
|
Inf
|
0.913
|
0.913
|
0.3
|
ns
|
|
2
|
Folate_gp:Study
|
1
|
Inf
|
1.258
|
1.258
|
0.3
|
ns
|
HOMA-IR
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
Folate_gp
|
1
|
Inf
|
3.018
|
3.018
|
0.08
|
ns
|
|
3
|
Study
|
1
|
Inf
|
25.541
|
25.541
|
<0.0001
|
***
|
|
4
|
GA_samp
|
1
|
Inf
|
0.445
|
0.445
|
0.5
|
ns
|
|
2
|
Folate_gp:Study
|
1
|
Inf
|
1.185
|
1.185
|
0.3
|
ns
|
Glucose (mmol/L)
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
Folate_gp
|
1
|
Inf
|
0.159
|
0.159
|
0.7
|
ns
|
|
3
|
Study
|
1
|
Inf
|
111.887
|
111.887
|
<0.0001
|
***
|
|
4
|
GA_samp
|
1
|
Inf
|
0.556
|
0.556
|
0.5
|
ns
|
|
2
|
Folate_gp:Study
|
1
|
Inf
|
0.203
|
0.203
|
0.7
|
ns
|
Model summary
Ratio of Geometric means (95% CI)
PRL (ng/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
15.51 (10.89, 22.08)
|
<0.0001
|
|
Folate_gp≥45.3
|
0.94 (0.88, 1.00)
|
0.06
|
|
StudySTOP
|
0.99 (0.89, 1.10)
|
0.85
|
|
GA_samp
|
1.15 (1.13, 1.18)
|
<0.0001
|
hPL (μg/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
1.86 (1.55, 2.23)
|
<0.0001
|
|
Folate_gp≥45.3
|
0.99 (0.96, 1.03)
|
0.72
|
|
StudySTOP
|
1.12 (1.06, 1.18)
|
0.0001
|
|
GA_samp
|
1.34 (1.32, 1.36)
|
<0.0001
|
GH2 (ng/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
0.07 (0.06, 0.10)
|
<0.0001
|
|
Folate_gp≥45.3
|
0.96 (0.92, 1.01)
|
0.13
|
|
StudySTOP
|
0.99 (0.92, 1.07)
|
0.78
|
|
GA_samp
|
1.30 (1.28, 1.32)
|
<0.0001
|
Insulin (uU/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
12.69 (8.04, 20.00)
|
<0.0001
|
|
Folate_gp≥45.3
|
0.90 (0.82, 0.99)
|
0.03
|
|
StudySTOP
|
0.80 (0.69, 0.92)
|
0.002
|
|
GA_samp
|
1.01 (0.99, 1.04)
|
0.34
|
HOMA-IR
|
Var
|
Effect
|
P
|
|
(Intercept)
|
3.24 (2.00, 5.24)
|
<0.0001
|
|
Folate_gp≥45.3
|
0.90 (0.81, 0.99)
|
0.03
|
|
StudySTOP
|
0.69 (0.59, 0.80)
|
<0.0001
|
|
GA_samp
|
1.01 (0.98, 1.04)
|
0.50
|
Glucose (mmol/L)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
5.68 (5.19, 6.20)
|
<0.0001
|
|
Folate_gp≥45.3
|
1.00 (0.98, 1.02)
|
0.73
|
|
StudySTOP
|
0.86 (0.84, 0.88)
|
<0.0001
|
|
GA_samp
|
1.00 (0.99, 1.00)
|
0.45
|
Estimated means
Estimated marginal means (or adjusted means) adjusted for GA at sampling.
PRL (ng/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
96.00630
|
7.195117
|
86.43610
|
82.71826
|
111.4290
|
|
STOP
|
95.07406
|
6.813547
|
72.37696
|
82.41817
|
109.6733
|
hPL (μg/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
88.26468
|
2.363507
|
155.2526
|
83.71723
|
93.05914
|
|
STOP
|
98.64043
|
2.427366
|
110.9325
|
93.94580
|
103.56966
|
GH2 (ng/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
2.307938
|
0.0656473
|
440.8614
|
2.182457
|
2.440633
|
|
STOP
|
2.283240
|
0.0546164
|
255.4347
|
2.178178
|
2.393369
|
Insulin (uU/ml)
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
14.52554
|
0.7204407
|
Inf
|
13.17996
|
16.00848
|
|
STOP
|
11.56468
|
0.4431398
|
Inf
|
10.72796
|
12.46667
|
HOMA-IR
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
3.525094
|
0.1852528
|
Inf
|
3.180079
|
3.907541
|
|
STOP
|
2.417761
|
0.0982142
|
Inf
|
2.232728
|
2.618128
|
Glucose (mmol/L)
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
5.490652
|
0.0518795
|
Inf
|
5.389906
|
5.593281
|
|
STOP
|
4.724282
|
0.0359866
|
Inf
|
4.654274
|
4.795344
|
Comparisons (Overall)
|
Hormone
|
Contrast
|
Ratio of Geometric means (95% CI)
|
P-value
|
|
PRL (ng/ml)
|
≥45.3 / <45.3
|
0.94 (0.88, 1.00)
|
0.06
|
|
hPL (μg/ml)
|
≥45.3 / <45.3
|
0.99 (0.96, 1.03)
|
0.7
|
|
GH2 (ng/ml)
|
≥45.3 / <45.3
|
0.96 (0.92, 1.01)
|
0.1
|
|
Insulin (uU/ml)
|
≥45.3 / <45.3
|
0.90 (0.82, 0.99)
|
0.03
|
|
HOMA-IR
|
≥45.3 / <45.3
|
0.90 (0.81, 0.99)
|
0.03
|
|
Glucose (mmol/L)
|
≥45.3 / <45.3
|
1.00 (0.98, 1.02)
|
0.7
|
Diagnostics
Model diagnositcs.
Diagnositcs for PRL (ng/ml)

Diagnositcs for hPL (μg/ml)

Diagnositcs for GH2 (ng/ml)

Diagnositcs for Insulin (uU/ml)

Diagnositcs for HOMA-IR

Diagnositcs for Glucose (mmol/L)
